Back to SenseLab
Membrane Properties: Neurotransmitters/neuromodulators
This inventory gives a complete overview of the main types of neurotransmitters and neuromodulators that have been identified. Supporting data to fill the tables is still being added. The list of neurotransmitters and neuromodulators for NeuronDB is a subset of this inventory. The inventory is based on Alexander & Peters (2000)
| Neurotransmitters/Neuromodulators | Receptors |
|---|---|
| Acetylcholine | Acetylcholine receptors, muscarinic, nicotinic |
| Adenosine | Adenosine receptors |
| adrenaline (aka epinephrine) | Adrenoceptors , alpha,beta |
| Angiotensin (Ang II, Ang III) | Angiotensin receptors |
| Atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP), type C-natriuretic peptide (CNP) | Atrial natriuretic peptide receptors |
| Gastrin-releasing peptide (GRP), neuromedin B (NMB) | Bombesin receptors |
| Bradykinin (BK) | Bradykinin receptors |
| Calcitonin, amylin, CGRP, adrenomedullin | Calcitonin, amylin, CGRP and adrenomedullin receptors |
| Cannabinoid | Cannabinoid receptors |
| CC Chemokines. CXC Chemokines. CX3C Chemokines. | Chemokine receptors, CC, CX3C |
| C3a, C5a | Chemotactic peptide receptors |
| Cholecystokinin (CCK)-4, CCK-8, CCK-33, gastrin | Cholecystokinin and gastrin receptors |
| Corticotropin-releasing factor (CRF), aka Corticotropin-releasing hormone (CRH), urocortin | Corticotropin-releasing factor rceptors |
| Dopamine | Dopamine receptors |
| Endothelin-1 (ET-1) , ET-2, ET-3 | Endothelin receptors |
| GABA | GABA receptors |
| Galanin and galanin-like peptides (GALP) | Galanin receptors |
| Glutamate | Glutamate receptors, Ionotropic Glutamate |
| Glutamate, L-aspartate, etc. | Metabotropic Glutamate receptors |
| Glycine, beta-alanine, taurine | Glycine receptors |
| Glycoprotein hormone(s): ….eg . FSH (follitropin, follicle-stimulating hormone), LH (Lutriopin, Luteinizing hormone), CG (choriogonadotropin, chorionic gonadotropin), TSH (thyrotropin, thyroid-stimulation hormone) | Glycoprotein hormone receptors |
| Histamine | Histamine receptors |
| 5-Hydroxytryptamine (5-HT, serotonin) | 5-Hydroxytryptamine receptors |
| Ins(1,4,5)P3(IP3) cytosolic Ca, cytosolic ATP. | Ins(1,4,5)P3(IP3) receptors |
| Leukotriene (LT) B4 LTC4 LTD4 LTE4 etc | Leukotriene receptors |
| Sphingosine-1-phosphate(S1P) , sphingosylphosphorylcholine(SPC), lysophosphatidic acid (LPA) | Lysophospholipid receptors |
| Melanocortin (MSH), and adrenocorticotrophin (ACTH) | Melanocortin receptors |
| Melatonin (MLT), N-acetylserotonin | Melatonin receptors |
| Neuropeptide Y (NPY), pancreatic polypeptide (PP) | Neuropeptide Y receptors |
| Neurotensin. | Neurotensin receptors |
| Neurotrophin (NT), Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF) | Neurotrophin receptors |
| [Leu]enkephalin, b-endorphin, a-neo-dynorphin, dynorphin A (dyn A) dynorphin B, etc. | Opioid and opioid-like receptors |
| ATP 2-MeSATP | P2X receptors (transmitter-gated channels) |
| ATP, UTP, ADP, UDP, Ap3A, Ap4A, Ap5A, etc, etc. | P2Y receptors (G-protein-coupled) |
| Peroxisome proliferator : e.g. hypolipidaemic drugs, fatty acids . | Peroxisome proliferator activated receptors |
| Endogenous ligands Prostaglandin (PG) D, E, F, H, Prostacyclin , thromboxane A2 | Prostanoid receptors |
| Receptors activated by proteolytic cleavage of their aminal terminal exodomains. Endogenous activator: thrombin | Protease-activated receptors |
| endogenous activators: Cytosolic Ca, cytolic ATP,luminal Ca, CaM Kinase, PKA. Pharmacological activators: Ryanodine, caffeine suramin | Ryanodine receptors |
| Somatostatin-14 (SRIF-14), SRIF-28, cortistatin (CST-14) | Somatostatin receptors |
| Steroid hormones: 5a-Dihydrotestosterone (DHT), aldosterone, cortisol, cortisosterone, testosterone. | Steroid hormone receptors |
| Substance P (SP), neurokinin A (NKA), neurokinin B, neuropeptide K, neuropeptide g | Tachykinin receptors |
| Thyrotropin-releasing hormone (TRH) | Thyrotropin-releasing hormone receptors |
| Vasoactive intentinal peptide (VIP) pituitary adenylate cyclase activating peptide (PACAP) peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM), peptide histidine valine, growth hormone-releasing factor (GRF) | Vasoactive intentinal peptide and pituitary adenylate cyclase activating peptide receptors |
| Arginine Vasopressin (VP) , oxytocin (OT) | Vasopressin and oxytocin receptors |
| Nitric oxide (NO) | NO receptors (sGC, soluble guanylate cyclase?) |
| Carbon monoxide (CO) |
Reference:
Alexander, S.P.H. and Peters, J.A. (2000) Receptor and Ion Channel Nomenclature Supplement. Trends in Pharmacological SciencesQuestions, comments, problems? Email the NeuronDB
Administrator
This site is Copyright 2000
Shepherd Lab, Yale University