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Pathological mechanism
Name
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Reduces
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Process
Dendritic spine motility
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Rolipram
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Pharmacological Action
Blocks
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Brain region
Hippocampus
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Neuron
CA1 pyramidal neuron
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Cell model
Brain slice preparations
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Cellular compartment
PubMed ID
16962789
Citation
AlzWeb
Notes
Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Mol Cell Neurosci. 2006 Nov;33(3):274-82. Exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
"
Revisions:
1
Last time:
6/17/2008 11:57:58 AM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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