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Pathological mechanism
Name
NGF restores dendritic spine density in Layer V pyramidal neurons
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
Nerve Growth Factor (NGF)
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Intracelular pathological element
Pathological action
Increases
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Process
Dendritic spine density
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Visual & Motor
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Neuron
Neocortical pyramidal neuron: deep
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Cell model
Golgi impregnation - Animal post-mortem brains
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Cellular compartment
Distal apical dendrite
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PubMed ID
1723258
Citation
AlzWeb
Notes
Mervis, R. F., Pope, D., Lewis, R., Dvorak, R. M., & Williams, L. R. (1991). Exogenous nerve growth factor reverses age-related structural changes in neocortical neurons in the aging rat. A quantitative golgi study. Annals of the New York Academy of Sciences, 640, 95-101. NGF treatment restored dendritic spine densities to those seen in young controls on terminal tip segments ("plastic" regions). Internal branch segments ("nonplastic" regions) showed no response to NGF.
Pathology
Stage
Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
NGF restores dendritic spine density in Layer V pyramidal neurons
"
Revisions:
2
Last time:
6/17/2008 1:50:33 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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