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Pathological mechanism
Name
Abeta (1-42) increases dopamine release in the prefrontal cortex
Description
Hypothesis
Nicotinic Receptor Hypothesis
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Extracelular pathological element
Beta-amyloid (1-42)
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Intracelular pathological element
Pathological action
Increases
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Process
Process action
Transmitter(s)
Dopamine
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Receptor(s)
Channel(s)
Pharmacological Agent
alpha7 nicotinic receptor antagonists
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Pharmacological Action
Blocks
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Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
17935702
Citation
AlzWeb
Notes
In the presence of tetrodotoxin, Abeta(1-42) at 100 nM evoked the release of dopamine to approximately 170% of basal levels in the pre-frontal cortex. The Abeta(1-42)-evoked dopamine release was sensitive to antagonists of alpha7 nicotinic receptors.
Pathology
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Abeta (1-42) increases dopamine release in the prefrontal cortex
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Revisions:
3
Last time:
7/31/2008 11:59:51 AM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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