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Pathological mechanism
Name
Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
Description
Hypothesis
Nicotinic Receptor Hypothesis
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Inhibits
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Process
Wnt/beta-catenin signalling
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Nicotine
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Pharmacological Action
Protects
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Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
18652670
Citation
AlzWeb
Notes
Abeta binds to the extracellular cysteine-rich domain of the Frizzled receptor (Fz) inhibiting Wnt/beta-catenin signaling. Cross-talk with other signaling cascades that regulate Wnt/beta-catenin signaling, including the activation of M1 muscarinic receptor and PKC, the use of Ibuprofen-ChE bi-functional compounds, PPAR alpha, gamma agonists, nicotine and some antioxidants, results in neuroprotection against Abeta. Inestrosa, N. C., & Toledo, E. M. (2008). The role of wnt signaling in neuronal dysfunction in alzheimer's disease. Molecular Neurodegeneration, 3(1), 9.
Pathology
Stage
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Other categories referring to "
Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
"
Revisions:
3
Last time:
7/30/2008 5:09:13 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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