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Pathological mechanism
Name
Model block of I_A
Description
Hypothesis
Dendritic Hypothesis - K+ current
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Inhibits
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Process
Process action
Transmitter(s)
Receptor(s)
Channel(s)
I A
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Pharmacological Agent
Pharmacological Action
Brain region
Hippocampus
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Neuron
CA1 pyramidal neuron
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Cell model
Cellular compartment
General or unspecified
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PubMed ID
8986775
Citation
8986775
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AlzWeb
Notes
A model shows that block of I_A is sufficient to cause membrane depolarization, calcium influx, and increased excitability (Good TA, Murphy RM 1996).
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Other categories referring to "
Model block of I_A
"
Revisions:
8
Last time:
7/31/2008 12:20:18 PM
Reviewer:
Pradeep Mutalik
Owner:
EAV/CR Schema Administrator
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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