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Pathological mechanism
Name
beta-Amyloid impairs LTP/LTD
Description
Hypothesis
LTP hypothesis
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Inhibits
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Process
LTP
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Process action
independent of
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Transmitter(s)
Receptor(s)
NMDA
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Channel(s)
I Calcium
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Pharmacological Agent
Pharmacological Action
Brain region
Hippocampus
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Neuron
CA1 pyramidal neuron
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Cell model
Cellular compartment
Dendrite
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PubMed ID
16154266
Citation
16154266
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AlzWeb
Notes
Impairment of LTP by beta-Amyloid is independent of NMDA receptors or voltage dependent Ca currents (Nomura I et al. 2005)
Pathology
Alzheimer
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Stage
Question
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Other categories referring to "
beta-Amyloid impairs LTP/LTD
"
Revisions:
11
Last time:
11/25/2009 11:36:22 AM
Reviewer:
EAV/CR Schema Administrator
Owner:
EAV/CR Schema Administrator
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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