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Pathological mechanism
Name
beta Amyloid increases calcium currents (2)
Description
Hypothesis
Dendritic Hypothesis - Ca++ currents
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Increases
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Process
Process action
Transmitter(s)
Receptor(s)
Channel(s)
I Calcium
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Pharmacological Agent
Nifedipine
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Pharmacological Action
Blocks
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Brain region
Hippocampus
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Neuron
CA1 pyramidal neuron
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Cell model
Cellular compartment
General or unspecified
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PubMed ID
12207918
Citation
12207918
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AlzWeb
Notes
"...beta-Amyloid(1-40) is related to an increase of non-L-type Ca channels ..." (Rovira C, et al. 2002).
Pathology
Alzheimer
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Stage
Question
Claim
Increased excitability can increase Ca++ influx causing synaptic effects and excitotoxicity
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Other categories referring to "
beta Amyloid increases calcium currents (2)
"
Revisions:
3
Last time:
7/31/2008 12:12:30 PM
Reviewer:
Pradeep Mutalik
Owner:
Luis Marenco
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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