SenseLab
Brain Pharmacology Database
User:
Public
Home
Neurons
Pathological Mechanisms
Data
Search
Schema
Login
Go back
[
Data
]
Pathological mechanism
Name
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
Description
Hypothesis
Extracelular pathological element
β-Amyloid
show other
Intracelular pathological element
Pathological action
Inhibits
show other
Process
LTP
show other
Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Hippocampus
show other
Neuron
Cell model
Cellular compartment
Dendrite
show other
PubMed ID
16549764
Citation
AlzWeb
Notes
Abeta42/Abeta40 ratio correlates with impaired LTP and with dendritic spine density and behavioral competence in the Tg2576 mouse model of AD. This happens before there is any significant increase in beta amyloid levels. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE. Proc Natl Acad Sci U S A. 2006 Mar 28, 103(13):5161-6.
Pathology
Alzheimer
show other
Stage
Early
show other
Question
Claim
Other categories referring to "
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
"
Revisions:
1
Last time:
5/29/2008 10:18:56 AM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
Questions, comments, problems? Email the
Database Administrator
This site is Copyright 2011, Yale Center for Medical Informatics