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Pathological mechanism
Name
Abeta decreases dedritic spine number and alters dendritic spine morpholology
Description
Hypothesis
Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Induces
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Process
Dendritic Spine Loss
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Neuron
Cerebellar purkinje cell
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Cell model
Cellular compartment
Dendrite
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PubMed ID
18438727
Citation
AlzWeb
Notes
A review of loss or alteration of dendritic spines induced by the amyloid beta (Abeta) peptide in the context of AD. Dendritic spine loss and synaptic alterations in Alzheimer's disease.Knobloch M, Mansuy IM. Mol Neurobiol. 2008 Feb;37(1):73-82.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Shepherd Dendritic Hypothesis
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Other categories referring to "
Abeta decreases dedritic spine number and alters dendritic spine morpholology
"
Revisions:
2
Last time:
11/21/2008 10:42:21 AM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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