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Pathological mechanism
Name
Regulation of back-propagating action potentials in hippocampal neurons.
Description
Hypothesis
Dendritic hypothesis
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Extracelular pathological element
Intracelular pathological element
protein kinase C
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Pathological action
Inhibits
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Process
Process action
Transmitter(s)
Receptor(s)
Channel(s)
I Sodium
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Pharmacological Agent
Pharmacological Action
Brain region
Hippocampus
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Neuron
CA1 pyramidal neuron
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Cell model
Cellular compartment
Apical dendrite
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PubMed ID
10811726
Citation
AlzWeb
Notes
Johnston, D., Hoffman, D. A., Colbert, C. M., & Magee, J. C. (1999). Regulation of back-propagating action potentials in hippocampal neurons. Current Opinion in Neurobiology, 9(3), 288-292. Protein kinase C modulates the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Back-propagating action potentials influence LTP and LTD
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Other categories referring to "
Regulation of back-propagating action potentials in hippocampal neurons.
"
Revisions:
1
Last time:
6/3/2008 5:06:19 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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