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Pathological mechanism
Name
Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
Intracelular pathological element
Drebrin
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Pathological action
Is Correlated with
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Process
Cognitive Decline in Alzheimer's
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Neostriatum
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Neuron
Cell model
Human Post-mortem Study
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Cellular compartment
PubMed ID
16783169
Citation
AlzWeb
Notes
Counts, S. E., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006). Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Journal of Neuropathology and Experimental Neurology, 65(6), 592-601. Levels of DRB, a dendritic spine plasticity marker, were reduced approximately 40% to 60% in all cortical regions in AD compared with normals.In contrast, DRB levels in the superior frontal cortex increased approximately 30% in AD subjects.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
"
Revisions:
1
Last time:
6/4/2008 11:51:13 AM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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