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Pathological mechanism
Name
Amyloid plaques increase elimination of dendritic spines
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
Amyloid plaques
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Intracelular pathological element
Pathological action
Increases
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Process
Dendritic Spine Loss
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Neuron
Cell model
Brain slice preparations
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Cellular compartment
Dendrite
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PubMed ID
17717139
Citation
AlzWeb
Notes
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT.Am J Pathol. 2007 Oct;171(4):1304-11. In control animals, spine formation and elimination were equivalent over 1 hour of observation ( approximately 5% of observed spines), resulting in stable spine density. However, in aged Tg2576 mice spine elimination increased, specifically in the immediate vicinity of plaques. Spine formation was unchanged, resulting in spine loss.
Pathology
Stage
Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
Amyloid plaques increase elimination of dendritic spines
"
Revisions:
1
Last time:
6/16/2008 1:41:58 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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