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Pathological mechanism
Name
Abeta decreases dendritic spine number, causes dysmorphic spine shapes
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Reduces
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Process
Dendritic spine density
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Process action
Decreases
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Transmitter(s)
Receptor(s)
Glutamate
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Channel(s)
Pharmacological Agent
alpha7 nicotinic receptor antagonists
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NMDA receptor blockers
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Pharmacological Action
Blocks
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Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
17368908
Citation
AlzWeb
Notes
Calabrese, B., Shaked, G. M., Tabarean, I. V., Braga, J., Koo, E. H., & Halpain, S. (2007). Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Molecular and Cellular Neurosciences, 35(2), 183-193. Within 1-2 h picomolar concentrations of cell-derived, soluble Abeta cause Clusters of presynaptic vesicle markers to decrease in size and number at glutamatergic but not GABAergic terminals. Dendritic spines also decreased in number and became dysmorphic, as spine heads collapsed and/or extended long protrusions. Simultaneous time-lapse imaging of axon-dendrite pairs revealed that shrinking spines sometimes became disconnected from their presynaptic varicosity. Concomitantly, miniature synaptic potentials decreased in amplitude and frequency. Spine changes were prevented by blockers of nAChRs and NMDARs. Washout of Abeta within the first day reversed these spine changes.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
Abeta decreases dendritic spine number, causes dysmorphic spine shapes
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Revisions:
3
Last time:
11/21/2008 12:51:18 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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