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Pathological mechanism
Name
DHA increases dendritic spines and synapses; enhanced by uridine and choline
Description
Hypothesis
Dendritic Spine Hypothesis
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Extracelular pathological element
Oral docosahexanoic acid (DHA)
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Intracelular pathological element
Pathological action
Increases
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Process
Dendritic spine density
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Choline
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Uridine
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Pharmacological Action
Increases
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Brain region
Neuron
Cell model
Golgi impregnation - Animal post-mortem brains
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Cellular compartment
PubMed ID
18631994
Citation
AlzWeb
Notes
DHA also affects synaptic transmission in mammalian brain. Brain cells of gerbils or rats receiving this fatty acid manifest increased levels of phosphatides and of specific presynaptic or postsynaptic proteins. They also exhibit increased numbers of dendritic spines on postsynaptic neurons. These actions are markedly enhanced in animals that have also received the other two circulating precursors for phosphatidylcholine, uridine (which gives rise to brain uridine diphosphate and cytidine triphosphate) and choline (which gives rise to phosphocholine). Cansev, M., Wurtman, R. J., Sakamoto, T., & Ulus, I. H. (2008). Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 4(1 Suppl 1), S153-S168.
Pathology
Stage
Question
Claim
Loss/alteration of dendritic spines in early Alzheimer's
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Other categories referring to "
DHA increases dendritic spines and synapses; enhanced by uridine and choline
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Revisions:
2
Last time:
7/30/2008 6:31:39 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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