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Pathological mechanism
Name
Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
Description
Hypothesis
Extracelular pathological element
Abeta-derived diffusible ligands (ADDLs)
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Intracelular pathological element
Pathological action
Induces
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Process
Synapse Loss
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Process action
Binds at or near
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Transmitter(s)
Receptor(s)
NMDA
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Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
18165846
Citation
AlzWeb
Notes
ADDL binding instigates synapse loss, oxidative damage, and AD-type tau hyperphosphorylation.ADDLs act as pathogenic gain-of-function ligands that target particular synapses, binding to synaptic spines at or near NMDA receptors. Subsequent ADDL-induced abnormalities in spine morphology and synaptic receptor composition. Viola, K. L., Velasco, P. T., & Klein, W. L. (2008). Why alzheimer's is a disease of memory: The attack on synapses by A beta oligomers (addls). The Journal of Nutrition, Health & Aging, 12(1), 51S-57S.
Pathology
Alzheimer
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Stage
Early
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Question
Claim
Other categories referring to "
Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
"
Revisions:
4
Last time:
11/24/2008 12:29:55 PM
Reviewer:
Pradeep Mutalik
Owner:
Pradeep Mutalik
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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