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Pathological mechanism
Name
Aluminum alters GABAA receptors
Description
Hypothesis
Extracelular pathological element
Aluminum
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Intracelular pathological element
Pathological action
Potentiates
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Process
Cognitive Decline in Alzheimer's
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Process action
Alters
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Transmitter(s)
Receptor(s)
GabaA
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Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Olfactory Bulb
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Neuron
Olfactory bulb mitral cell
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Cell model
Cellular compartment
Dendrite
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Soma
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PubMed ID
9705466
Citation
9705466
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AlzWeb
Notes
" ... aluminum can alter the function of GABAA receptors and may suggest that aluminum can contribute to cognitive impairment through disruption of inhibitory circuits." (Trombley PQ 1998)
Pathology
Stage
Early
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Question
Claim
Other categories referring to "
Aluminum alters GABAA receptors
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Revisions:
7
Last time:
9/9/2008 10:55:46 AM
Reviewer:
Pradeep Mutalik
Owner:
EAV/CR Schema Administrator
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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