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Pathological mechanism
Name
Abeta modulates A current (HEK293 cells)
Description
Hypothesis
Dendritic Hypothesis - K+ current
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Extracelular pathological element
β-Amyloid
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Intracelular pathological element
Pathological action
Modulates
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Process
Process action
Transmitter(s)
Receptor(s)
Channel(s)
I Potassium
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Pharmacological Agent
Pharmacological Action
Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
16271805
Citation
16271805
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AlzWeb
Notes
"Control of neuronal spiking patterns resides, in part, in the type and degree of expression of voltage-gated K(+) channel subunits. Abeta is a modulator of Kv4 subunit expression in neurones at both the functional and the molecular level. Thus Abeta is not only involved in Alzheimer pathology, but is also an important physiological regulator of ion channel expression and hence neuronal excitability." (Plant LD et al. 2005)
Pathology
Alzheimer
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Stage
Early
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Question
Claim
A-type K+ channel block makes dendrites more excitable
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Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable
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Other categories referring to "
Abeta modulates A current (HEK293 cells)
"
Revisions:
8
Last time:
7/31/2008 12:05:13 PM
Reviewer:
Pradeep Mutalik
Owner:
EAV/CR Schema Administrator
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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