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Pathological mechanism
Name
Synaptic integration is disrupted in an AD mouse model
Description
Hypothesis
Extracelular pathological element
Beta amyloid plaques
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Intracelular pathological element
Pathological action
Inhibits
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Process
Evoked Synaptic response
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Process action
Transmitter(s)
Receptor(s)
Channel(s)
Pharmacological Agent
Pharmacological Action
Brain region
Neuron
Cell model
Cellular compartment
PubMed ID
15140924
Citation
15140924
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AlzWeb
Notes
The evoked synaptic response of neurons to transcallosal stimuli is severely impaired in cortex containing substantial plaque accumulation, with an average 2.5-fold greater rate of response failure and twofold reduction in response precision compared with age-matched nontransgenic controls. ... results show that plaques disrupt the synchrony of convergent inputs, reducing the ability of neurons to successfully integrate and propagate information. (Stern et al. 2004)
Pathology
Alzheimer
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Stage
Question
Claim
Other categories referring to "
Synaptic integration is disrupted in an AD mouse model
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Revisions:
5
Last time:
11/21/2008 10:27:08 AM
Reviewer:
Pradeep Mutalik
Owner:
Tom Morse
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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