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Computational model
Name
Roles of subthalamic nucleus and DBS in reinforcement conflict-based decision making (Frank 2006)
Model File
Conflict_DBS.zip
[? bytes]
Notes
Deep brain stimulation (DBS) of the subthalamic nucleus dramatically improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. This model from Frank (2006) simulates the role of the subthalamic nucleus (STN) within the basal ganglia circuitry in decision making. The STN dynamically modulates network decision thresholds in proportion to decision conflict. The STN ``hold your horses'' signal adaptively allows the system more time to settle on the best choice when multiple options are valid. The model also replicates effects in Parkinson's patients on and off DBS in experiments designed to test the model (Frank et al, 2007).
Model Neurons
Neostriatal spiny neuron
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Nigral dopaminergic cell
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More Cells
Globus pallidus neuron
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Subthalamic projection neuron
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Model Currents
Model Receptors
Model Type
Connectionist Network
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Model Concept
Parkinson's
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Rate-coding model neurons
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Rebound firing
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Reinforcement Learning
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Simplified Models
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Synaptic Plasticity
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Action Selection/Decision Making
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Deep brain stimulation
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Model papers
Frank MJ (2006)
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Frank MJ, Samanta J, Moustafa AA, Sherman SJ (2007)
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Simulator software
Emergent/PDP++
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Gene
hg folder name (applicable when in ModelDB hg)
Region Organism
Model ID Number
Gap Junctions
Implemented by
Frank, Michael [mfrank at u.arizona.edu]
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Read write access code
Public Submitter Email Address
mfrank@u.arizona.edu
Model Neurotransmitters
Gaba
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Glutamate
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Dopamine
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Other Neurotransmitter
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Other Implementer
Frank, Michael
Alternative Version
Citation
Frank, M.J. (2006). Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making. Neural Networks, 19, 1120-1136.
Default File Notes
Other Gene
Simulation Platform ID
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0
Other categories referring to "
Roles of subthalamic nucleus and DBS in reinforcement conflict-based decision making (Frank 2006)
"
Revisions:
10
Last time:
11/12/2010 4:03:07 PM
Reviewer:
Tom Morse - MoldelDB admin
Owner:
Tom Morse - MoldelDB admin
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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