Pathological mechanism having Early as Stage

Name/Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      3 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice      4 Abeta decreases dedritic spine number and alters dendritic spine morpholology      5 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      6 Abeta decreases dendritic spine number, causes dysmorphic spine shapes      7 Abeta inhibits late LTP in animal models of Alzheimers      8 Abeta inhibits LTP both in soluble and fibrillar conformational states      9 Abeta inhibits LTP through TNFalpha      10 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals       11 Abeta modulates A current (HEK293 cells)      12 Abeta peptides block LTP in rat CA1 in vivo      13 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors      14 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers      15 Alpha4beta2 receptor blockade causes memory impairment      16 Aluminum alters GABAA receptors      17 AMPA receptor downscaling in AD      18 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density      19 BACE1 required for LTP at mossy fiber-CA3 synapses      20 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      21 beta-amyloid reduces IA      22 beta-Amyloid-induced depression of LTP attenuated by Verapamil      23 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease      24 Histidine associating compounds block Abeta Channel activity and cytotoxicity      25 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice      26 LTP requires BDNF and is associated with cytoskeleton-associated protein      27 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist      28 Model block of I_A      29 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla      30 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo      31 Picomolar concentrations of abeta monomers disrupt LTP      32 Regulation of back-propagating action potentials in hippocampal neurons.      33 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice      34 The channel hypothesis of Alzheimers disease