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Pathological mechanism
having
Alzheimer
as
Pathology
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Notes
1
Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
2
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
4
Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
5
Abeta decreases dedritic spine number and alters dendritic spine morpholology
6
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
7
Abeta decreases dendritic spine number, causes dysmorphic spine shapes
9
Abeta inhibits late LTP in animal models of Alzheimers
10
Abeta inhibits LTP both in soluble and fibrillar conformational states
11
Abeta inhibits LTP through TNFalpha
12
Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
14
Abeta modulates A current (HEK293 cells)
17
Abeta peptides block LTP in rat CA1 in vivo
18
Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
19
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
25
Alpha4beta2 receptor blockade causes memory impairment
26
AMPA receptor downscaling in AD
27
Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
28
BACE1 required for LTP at mossy fiber-CA3 synapses
30
beta Amyloid increases calcium currents (2)
32
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
33
beta-Amyloid impairs LTP/LTD
35
beta-amyloid reduces IA
36
beta-Amyloid-induced depression of LTP attenuated by Verapamil
37
Chronic nicotine decreases NGF and improves memory performance
39
Donepezil modulates potassium channels
40
Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
42
Galantamine increases dopamine release in the hippocampus
44
Histidine associating compounds block Abeta Channel activity and cytotoxicity
47
Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
48
LTP requires BDNF and is associated with cytoskeleton-associated protein
50
Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist
51
Model block of I_A
52
Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
53
Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline
56
Nicotine desensitize alpha7 nACh receptors and facilitates LTP
57
Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
60
Okadaic acid mediates tau phosphorylation via L channel activation
65
p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
67
Picomolar concentrations of abeta monomers disrupt LTP
70
Presenilin-1 deficient neurons have increased activity of L channels
72
Protofibrillar intermediates of ABeta change firing pattern of neurons.
74
Regulation of back-propagating action potentials in hippocampal neurons.
76
Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice
78
Synaptic integration is disrupted in an AD mouse model
79
The channel hypothesis of Alzheimers disease
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