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Go back Pathological mechanism having Alzheimer as Pathology   Name/ Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      4 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice      5 Abeta decreases dedritic spine number and alters dendritic spine morpholology      6 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      7 Abeta decreases dendritic spine number, causes dysmorphic spine shapes      9 Abeta inhibits late LTP in animal models of Alzheimers      10 Abeta inhibits LTP both in soluble and fibrillar conformational states      11 Abeta inhibits LTP through TNFalpha      12 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals       14 Abeta modulates A current (HEK293 cells)      17 Abeta peptides block LTP in rat CA1 in vivo      18 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors      19 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers      25 Alpha4beta2 receptor blockade causes memory impairment      26 AMPA receptor downscaling in AD      27 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density      28 BACE1 required for LTP at mossy fiber-CA3 synapses      30 beta Amyloid increases calcium currents (2)      32 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      33 beta-Amyloid impairs LTP/LTD      35 beta-amyloid reduces IA      36 beta-Amyloid-induced depression of LTP attenuated by Verapamil      37 Chronic nicotine decreases NGF and improves memory performance      39 Donepezil modulates potassium channels      40 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease      42 Galantamine increases dopamine release in the hippocampus      44 Histidine associating compounds block Abeta Channel activity and cytotoxicity      47 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice      48 LTP requires BDNF and is associated with cytoskeleton-associated protein      50 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist      51 Model block of I_A      52 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla      53 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline      56 Nicotine desensitize alpha7 nACh receptors and facilitates LTP      57 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo      60 Okadaic acid mediates tau phosphorylation via L channel activation      65 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro      67 Picomolar concentrations of abeta monomers disrupt LTP      70 Presenilin-1 deficient neurons have increased activity of L channels      72 Protofibrillar intermediates of ABeta change firing pattern of neurons.      74 Regulation of back-propagating action potentials in hippocampal neurons.      76 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice      78 Synaptic integration is disrupted in an AD mouse model      79 The channel hypothesis of Alzheimers disease