ModelDB: ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)

ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)

Accession: 100603

"Blocking the small-conductance (SK) calcium-activated potassium channel promotes burst firing in dopamine neurons both in vivo and in vitro. ... We focus on the underlying plateau potential oscillation generated in the presence of both apamin and TTX, so that action potentials are not considered. We find that although the plateau potentials are mediated by a voltage-gated Ca2+ current, they do not depend on the accumulation of cytosolic Ca2+, then use a computational model to test the hypothesis that the slowly voltage-activated ether-a-go-go–related gene (ERG) potassium current repolarizes the plateaus. The model, which includes a material balance on calcium, is able to reproduce the time course of both membrane potential and somatic calcium concentration, and can also mimic the induction of plateau potentials by the calcium chelator BAPTA." See paper for more.
Reference: Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD (2007) Computational Model Predicts a Role for ERG Current in Repolarizing Plateau Potentials in Dopamine Neurons: Implications for Modulation of Neuronal Activity. J Neurophysiol 98:3006-3022 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):	Nigral dopaminergic cell;
Channel(s):	I L high threshold; I h; I K,Ca; I Calcium; I_HERG;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	C or C++ program; FORTRAN;
Model Concept(s):	Ion Channel Kinetics; Oscillations; Calcium dynamics;
Implementer(s):	Canavier, CC;

Search NeuronDB for information about: Nigral dopaminergic cell; I L high threshold; I h; I K,Ca; I Calcium; I_HERG;

Model files

Help downloading and running models

The parameters are set to replicate Fig 6D in

Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD. Computational
Model Predicts a Role for ERG in Repolarizing Plateau Potentials in
Dopamine Neurons: Implications for Modulation of Neuronal
Activity. J. Neurophysiol 98:3006-3022. 2007

The output is the time followed by the state variables for voltage,
fraction of activated ERG channels, activation of the calcium channel,
calcium, activation of the H current, and fraction of inactivated of
the ERG channels.

------

To run the programs in linux/unix, after extracting the files and
cd'ing to the directory you can type:

make koprisan
./koprisan > output.dat

and then make plots for example with octave

load output.dat
plot (output(:,1),output(:,2))

which shows the voltage time series:

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University