ModelDB: O-LM interneuron model (Lawrence et al. 2006)

O-LM interneuron model (Lawrence et al. 2006)

Accession: 102288

Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.
Reference: Lawrence JJ, Saraga F, Churchill JF, Statland JM, Travis KE, Skinner FK, McBain CJ (2006) Somatodendritic Kv7-KCNQ-M channels control interspike interval in hippocampal interneurons. J Neurosci 26:12325-38 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	CA1 oriens alveus interneuron;
Channel(s):	I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
Gap Junctions:
Receptor(s):	Muscarinic;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials;
Implementer(s):

Search NeuronDB for information about: CA1 oriens alveus interneuron; Muscarinic; I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;

Model files

Help downloading and running models

initactiveproxStarfish.hoc

mosinit.hoc

initactivesdRichy.hoc

initactivesdStarfish.hoc

initactiveproxRichy.hoc

Starfishtrunc.hoc

This is the readme for the model associated with the paper:

Lawrence JJ, Saraga F, Churchill JF, Statland JM, Travis KE, Skinner FK,
McBain CJ (2006) Somatodendritic Kv7-KCNQ-M channels control interspike
interval in hippocampal interneurons. J Neurosci 26:12325-38

Usage:
Auto-launch from ModelDB or download and extract the archive and then under

ms-win
------
Compile the mod files by running mknrndll and changing to the extracted
folder and selecting to create the nrnmech.dll.  Then double click on
the mosinit.hoc file

linux/unix
----------
Compile the mod files by running nrnivmodl in the extracted folder.  Then
run "nrngui mosinit.hoc"

mac os x
--------
Drag and drop the extracted folder onto the mknrndll icon.  Drag and drop
the mosinit.hoc file from the extracted folder onto the nrngui icon.

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Once the simulation starts you can create subplots of Fig 9 by clicking
the appropriately labeled buttons or you can create the whole figure by
clicking the create all of fig 9 button (lower right in control box)
and you will get a figure like:



Note: The variable step method was used in this demo, if you would like
to run the simulation as in the publication you can run cvode_active(0).

The model files were supplied by Dr Saraga.

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