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Activity constraints on stable neuronal or network parameters (Olypher and Calabrese 2007)
Accession: 112348
"In this study, we developed a general description of parameter combinations for which specified characteristics of neuronal or network activity are constant. Our approach is based on the implicit function theorem and is applicable to activity characteristics that smoothly depend on parameters. Such smoothness is often intrinsic to neuronal systems when they are in stable functional states. The conclusions about how parameters compensate each other, developed in this study, can thus be used even without regard to the specific mathematical model describing a particular neuron or neuronal network. ..."
Reference: Olypher AV, Calabrese RL (2007) Using constraints on neuronal activity to reveal compensatory changes in neuronal parameters. J Neurophysiol 98:3749-58 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:  Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):   Leech heart interneuron;
Channel(s):  I T low threshold; I h; I Calcium;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  MATLAB (web link to model);
Model Concept(s):  Methods;
Implementer(s):  
Search NeuronDB for information about:  I T low threshold; I h; I Calcium;
Model files (located externally to ModelDB) Help downloading and running models
calabrese lab software Note from ModelDB administrator: This page is a copy of http://calabreselx.biology.emory.edu/software.html The model for Olypher and Calabrese 2007 is available through the first link below titled "Matlab code for ....".

Calabrese Lab Software

Last updated August 23, 2007 . Please send comments to aolifer@emory.edu.



Tutorial and model of the leech heartbeat timing network (Release 8/20/99)

This new tutorial includes introductory material, a graphical user interface to the model, and suggested experiments to help the user explore and understand the model.
You'll need three things to run the network leech model: 1) the GENESIS simulation program, 2) the GENESIS script files for the model and tutorial, and 3) an extension to GENESIS that is required by our GENESIS files. Items 2 and 3 are available at this site, and you can GENESIS at http://www.genesis-sim.org/GENESIS/. Instructions for running the model are contained in item 2.
  1. The GENESIS simulation program
  2. Extensions to GENESIS required by the model of Heart Interneuron Network:
Use 'tar -xvf filename.tar' to extract files from the tar archives above.

 


Last updated August 23, 2007 . Please send comments to terrence.m.wright@emory.edu.


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