ModelDB: Biophysical and phenomenological models of spike-timing dependent plasticity (Badoual et al. 2006)

Biophysical and phenomenological models of spike-timing dependent plasticity (Badoual et al. 2006)

Accession: 116096

"Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. ... A simplified phenomenological model is also derived..."
Reference: Badoual M, Zou Q, Davison AP, Rudolph M, Bal T, Fregnac Y, Destexhe A (2006) Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity. Int J Neural Syst 16:79-97 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I Na,t; I K; I M; I Calcium;
Gap Junctions:
Receptor(s):	AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Simplified Models; Synaptic Plasticity; Long-term Synaptic Plasticity; STDP;
Implementer(s):

Search NeuronDB for information about: AMPA; NMDA; I K; I Calcium; I M; I Na,t;

Model files

Help downloading and running models

This is the readme for this package which reproduces figures 2 and 3
from:
   
   M. Badoual, Q. Zou, A.P. Davison, M. Rudolph, T. Bal,
   Y. Fregnac and A. Destexhe (2006) Biophysical and phenomenological
   models of multiple spike interactions in spike-timing dependent
   plasticity.
   Int J. Neural Syst. 16: 79-97
   
For more information, see http://cns.iaf.cnrs-gif.fr/abstracts/STDP2005.html

How to run the model:
---------------------

Simply auto-launch the model from ModelDB or download and extract the
archive then under

MSWIN
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Run mknrndll, cd to the expanded directory and click on the make
nrnmech.dll button.  Under windows explorer double click on the
mosinit.hoc file

LINUX/UNIX
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Run nrnivmodl in the expanded archive folder.  Then type
nrngui mosinit.hoc

MAC OS X
--------

Drag and drop the expanded folder onto the mknrndll icon.  Drag and
drop the mosinit.hoc file onto the nrngui icon.

Once the simulation has started
-------------------------------

Select the button for the simulation that you would like to run.  For
example, selecting the Fig 2A button actually reproduces 2Aa, 2Ab, 2Ac
and 2Ad:



These model files were supplied by Andrew Davison.

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