ModelDB: Quantal neurotransmitter release kinetics with fixed and mobile Ca2+ buffers (Gilmanov et al. 2008)

Quantal neurotransmitter release kinetics with fixed and mobile Ca2+ buffers (Gilmanov et al. 2008)

Accession: 117351

"... In this work, we used computer modeling of quanta release kinetics with various levels of calcium influx and in the presence of endogenous calcium buffers with varying mobilities. The results of this modeling revealed the desynchronization of quanta release under low calcium influx in the presence of an endogenous fixed calcium buffer, with a diffusion coefficient much smaller than that of free Ca2+, and synchronization occurred upon adding a mobile buffer. This corresponds to changes in secretion time course parameters found experimentally ..."
Reference: Gilmanov IR, Samigullin DV, Vyskocil F, Nikolsky EE, Bukharaeva EA (2008) Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers. J Comput Neurosci 25:296-307 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Pascal (web link to model);
Model Concept(s):	Calcium dynamics;
Implementer(s):

Model files (located externally to ModelDB) Help downloading and running models

Note from the ModelDB Administrator:

the below is a copy of the web page http://timecourse.nm.ru on February 12th, 2009. The paper also mentions that the "Simulations were performed with custom-written codes using Free Pascal Compiler (www.freepascal.org)."

Some supplementary data for paper

MODELING OF QUANTAL NEUROTRANSMITTER RELEASE KINETICS IN THE PRESENCE OF FIXED AND MOBILE CALCIUM BUFFERS
Iskander R. Gilmanov1, Dmitry V. Samigullin1, Frantisek Vyskocil2, Eugeny E. Nikolsky1,3 Ellya A. Bukharaeva1,3

Source: tcr10.pas
Compiled executable: tcr10.exe
Example of file with settnigs: tcr10.ini

Settings for figure 3:

tcr10.ini for case with Ca flux 0.3 pA without buffers
resulting tcr10.tcr of case with Ca flux 0.9 pA without buffers

tcr10.ini for case with Ca flux 0.9 pA without buffers
resulting tcr10.tcr of case with Ca flux 0.9 pA without buffers

Settings for figure 4:

tcr10.ini for case with Ca flux 0.3 pA without buffers
resulting tcr10.tcr of case with Ca flux 0.9 pA without buffers

tcr10.ini for case with Ca flux 0.3 pA with mobile buffer only
resulting tcr10.tcr of case with Ca flux 0.3 pA with mobile buffer only

Settings for figure 5:

tcr10.ini for case with Ca flux 0.3 pA with mobile buffer only
resulting tcr10.tcr of case with Ca flux 0.3 pA with mobile buffer only

tcr10.ini for case with Ca flux 0.9 pA with mobile buffer only
resulting tcr10.tcr of case with Ca flux 0.9 pA with mobile buffer only

Settings for figure 6:

tcr10.ini for case with Ca flux 0.3 pA with fixed buffer only
resulting tcr10.tcr of case with Ca flux 0.3 pA with fixed buffer only

tcr10.ini for case with Ca flux 0.9 pA with fixed buffer only
resulting tcr10.tcr of case with Ca flux 0.9 pA with fixed buffer only

Settings for figure 7: