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Permeation and inactivation of CaV1.2 Ca2+ channels (Babich et al. 2007)
Accession: 118759
The authors present data and a kinetics model of the CaV1.2 channel supporting the idea that Ca2+ block of the pore generates the U-shaped inactivation curve.
Reference: Babich O, Matveev V, Harris AL, Shirokov R (2007) Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: does Ca2+ block the pore of inactivated channels? J Gen Physiol 129:477-83 [PubMed]
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Model Type:  Channel;
Brain Region(s)/Organism:  
Cell Type(s):   
Channel(s):  I L high threshold;  
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Simulation Environment:  CalC Calcium Calculator (web link to model);
Model Concept(s):  Ion Channel Kinetics;
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Search NeuronDB for information about:  I L high threshold;
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ca2+-dependent inactivation of cav1.2 channels Prevents Gd3+ Block: Does Ca2+ Block the Pore of Inactivated Channels? -- Babich et al. 129 (6): 477 Data Supplement - JGP--Babich et al. Supplemental Material Index -- The Journal of General Physiology

Note from the ModelDB Administrator: The below is a snapshot of the paper`s Journal of General Physiology supplemental material web page on April 9th 2009.

The Journal of General Physiology
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Index of Online Supplemental Material for
J. Gen. Physiol. 10.1085/jgp.200709734
Babich et al.

• Figure S1 Effect of series resistance (Rs) on simulated kinetics of inactivation.

• Figure S2 Effect of local Ca2+ accumulation on simulated kinetics of inactivation.

• Figure S3 Simulation of inactivation in Ba2+.

• cain.par (script text file) Equations, parameters of the model, and extensive comments

• cain2.par (script text file) A modification of cain.par to model the effect of Ca2+ accumulation





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