| Facilitation model based on bound Ca2+ (Matveev et al. 2006) |
| Accession: 118797 |
"Facilitation is a transient stimulation-induced increase in synaptic response, a
ubiquitous form of short-term synaptic plasticity that can regulate
synaptic transmission on fast time scales.
In their pioneering work, Katz and Miledi and Rahamimoff demonstrated the dependence of
facilitation on presynaptic Ca2+ influx and proposed that facilitation
results from the accumulation of residual Ca2+ bound to vesicle
release triggers.
However, this bound Ca2+ hypothesis appears to contradict the evidence that
facilitation is reduced by exogenous Ca2+ buffers.
This conclusion led to a widely held view that facilitation
must depend solely on the accumulation of Ca2+ in free form.
Here we consider a more realistic implementation of the bound Ca2+
mechanism, taking into account spatial diffusion of Ca2+, and show
that a model with slow Ca2+ unbinding steps can retain sensitivity to
free residual Ca2+.
..."
Reference: Matveev V, Bertram R, Sherman A (2006) Residual bound Ca2+ can account for the effects of Ca2+ buffers on synaptic facilitation. J Neurophysiol 96:3389-97 [PubMed] |
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Example Script Files for the "Calcium Calculator" Simulator
Note from the ModelDB Administrator: the below is a snapshot of the
authors web site on April 10th, 2009.
| Calcium Calculator Simulation Script Files | | | | |
The scripts following below reproduce the simulation results presented
in the manuscript:
The comments in these script files
provide a detailed step-by-step
description of the simulations.
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♦ ode.BCM.par
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This script file contains all ODE definitions (implementation of Eqs. 6-9). Place it in the same
directory with the files below before running the infividual figure scripts.
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♦ pde.BCM.par
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This script file contains all PDE definitions (implementation of Eqs. 2-5). Place it in the same
directory with the files below before running the infividual figure scripts.
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♦ demo.BCM.par
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reproduces Figures 2 and 3 of the manuscript. Use fura-2 concentration as command-line parameter.
Execute calc demo.BCM.par 0 to reproduce Fig. 2 and control data in Fig. 3.
Execute calc demo.BCM.par 400 to reproduce fura-2 data in Fig. 3.
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Victor Matveev
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Last modified: Oct 14, 2006
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