ModelDB: Nodose sensory neuron (Schild et al. 1994, Schild and Kunze 1997)

Nodose sensory neuron (Schild et al. 1994, Schild and Kunze 1997)

Accession: 120521

This is a simulink implementation of the model described in Schild et al. 1994, and Schild and Kunze 1997 papers on Nodose sensory neurons. These papers describe the sensitivity these models have to their parameters and the match of the models to experimental data.
References:
1. Schild JH, Kunze DL (1997) Experimental and modeling study of Na+ current heterogeneity in rat nodose neurons and its impact on neuronal discharge. J Neurophysiol 78:3198-209 [PubMed]
2. Schild JH, Clark JW, Hay M, Mendelowitz D, Andresen MC, Kunze DL (1994) A- and C-type rat nodose sensory neurons: model interpretations of dynamic discharge characteristics. J Neurophysiol 71:2338-58 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I Na,t; I N; I T low threshold; I A; I K; I K,Ca; Na/Ca exchanger;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	MATLAB (web link to model);
Model Concept(s):	Activity Patterns; Parameter Fitting; Calcium dynamics; Parameter sensitivity;
Implementer(s):	Snitsarev, Vladislav ;

Search NeuronDB for information about: I A; I K; I K,Ca; I N; I Na,t; I T low threshold;

Model files (located externally to ModelDB) Help downloading and running models

Press the below link to goto matlab central to download the model:

Simulink implementation of nodose neuron action potential firing with
parameters from the following studies:
 
Schild,J.H., Clark,J.W., Hay,M., Mendelowitz,D., Andresen,M.C., and
Kunze,D.L. (1994). A- and C-type rat nodose sensory neurons: model
interpretations of dynamic discharge characteristics.
J. Neurophysiol. 71, 2338-2358.
 
Schild,J.H., and Kunze,D.L. (1997). Experimental and modeling study of
Na+ current heterogeneity in rat nodose neurons and its impact on
neuronal discharge. J. Neurophysiol. 78, 3198-3209.
 
The screenshot image is the response to 0.04 nA current injection from
the resting membrane potential at 37C:

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