ModelDB: A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)

A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)

Accession: 120835

Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
Reference: Severi S, Corsi C, Rocchetti M, Zaza A (2009) Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 96:3862-72 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):	Cardiac ventricular cell;
Channel(s):	I_Ks;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Simulink;
Model Concept(s):	Ion Channel Kinetics;
Implementer(s):	Severi, Stefano [stefano.severi at unibo.it];

Search NeuronDB for information about: I_Ks;

Model files

Help downloading and running models

This is the readme for the model associated with the paper

Severi S, Corsi C, Rocchetti M, Zaza A (2009) Mechanisms of
beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle:
insights from experimental and model-based analysis.
Biophys J 96:3862-72

This simulink code is provided in an as-is state by Stefano Severi.
Parameters are set to reproduce the current response to a single
voltage step in control conditions.

Usage:
Start matlab and type

parametersIKs
Iks

on the command line to load initial conditions and the simulink model:



Select Simulation->Run in simulink, and then create a figure to see
the result:

plot(t,IKs)

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