SenseLab Home ModelDB Home

A network model of the vertebrate retina (Publio et al. 2009)
Accession: 124063
In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current Ih on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics.
Reference: Publio R, Oliveira RF, Roque AC (2009) A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina. PLoS One 4:e6970 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Network;
Brain Region(s)/Organism:  
Cell Type(s):  Retinal ganglion cell; Retinal photoreceptor; Retinal bipolar cell;  
Channel(s):   
Gap Junctions:  Gap junctions;
Receptor(s):  
Gene(s):  
Transmitter(s):  Glutamate;
Simulation Environment:  Neuron;
Model Concept(s):  Sensory processing;
Implementer(s):  Publio, Rodrigo [publio at oist.jp];
Search NeuronDB for information about:  Retinal ganglion cell; Retinal photoreceptor; Retinal bipolar cell; Glutamate;
Model files   Download zip file   Auto-launch             Help downloading and running models      Versions
\
PublioEtAl2009
README.html
screenshot1.jpg
screenshot2.jpg
Bip_Ca.mod
Bip_Cad.mod
Bip_ih.mod
Bip_Ka.mod
Bip_Kv.mod
Cone_CPR.mod
Cone_ih.mod
Cone_Kv.mod
Ganglion_hh.mod
gap.mod
IinjLT.mod
IinjLTDim.mod
IinjLT_cone.mod
Rod_Ca.mod
Rod_Cad.mod
Rod_Clca.mod
Rod_ih.mod
Rod_Kca.mod
Rod_Kv.mod
Rod_Kx.mod
Rod_leak.mod
A2hh_k.mod
A2hh_na.mod
syn_bip_gan.mod
syn_rod_bip.mod
createcells.hoc
init.hoc
mosinit.hoc
netconnection.hoc
parameters.hoc
gap.hoc
session.ses
Bip.tem
A2.tem
Cone.tem
Rod.tem
Ganglion.tem
                            
This is the readme for the model associated with paper:

Publio R,  Oliveira RF,  Roque AC, 2009
"A Computational Study on the Role of Gap Junctions and Rod Ih
Conductance in the Enhancement of the Dynamic Range of the Retina".
PLoS ONE 4(9): e6970. doi:10.1371/journal.pone.0006970  

These NEURON model files were contributed by Rodrigo Publio.

Recent works suggest that one of the roles of gap junctions in sensory
systems is to enhance their dynamic range by avoiding early saturation
in the first processing stages. In this work, we use a minimal
conductance-based model of the ON rod pathways in the vertebrate
retina to study the effects of electrical synaptic coupling via gap
junctions among rods and among AII amacrine cells on the dynamic range
of the retina. The model is also used to study the effects of the
maximum conductance of rod hyperpolarization activated current Ih on
the dynamic range of the retina, allowing a study of the
interrelations between this intrinsic membrane parameter with those
two retina connectivity characteristics. Our results show that for
realistic values of Ih conductance the dynamic range is enhanced by
rod-rod coupling, and that AII-AII coupling is less relevant to
dynamic range amplification in comparison with receptor
coupling. Furthermore, a plot of the retina output response versus
input intensity for the optimal parameter configuration is well fitted
by a power law with exponent ~0.5. The results are consistent with
predictions of more theoretical works and suggest that the earliest
expression of gap junctions along the rod pathways, together with
appropriate values of rod Ih conductance, has the highest impact on
vertebrate retina dynamic range enhancement.  ~

Figures 1 of "A Computational Study on the Role of Gap Junctions and
Rod Ih Conductance in the Enhancement of the Dynamic Range of the
Retina" can be replicated with this code, for example:

screenshot 1
screenshot 2

After compiling all MOD files load the appropriate HOC file (init.hoc)
from the neuron main menu after starting nrngui or by either double
clicking in mswin's window explorer, typing nrngui init.hoc in unix,
or dragging and dropping the init.hoc file onto the nrngui icon in Mac
OS X. Session files are called by the main HOC file.

The network dimensions and synaptic convergence/divergence are
specified at the parameters.hoc file. The cells are created from
templates at the createcells.hoc while gap junctions and chemical
synapses are created at netconnection.hoc.

20120326 Bip_Cad.mod and Rod_Cad.mod solve methods updated from euler
to derivimplicit as recommended in 
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592

ModelDB Home  SenseLab Home   Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University