ModelDB: CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

Accession: 125152

A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Reference: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel beta Subunits via Paradoxical Effects on Persistent Sodium Currents. J Neurosci 30:8489-501 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Detailed Neuronal Models; Epilepsy;
Implementer(s):	Horstmann, Marie-Therese [mhorstma at uni-bonn.de];

Search NeuronDB for information about: CA1 pyramidal neuron; I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;

Model files

Help downloading and running models

This is the readme for the model associated with the paper:

Uebachs et al. Efficacy loss of the anticonvulsant carbamazepine in
mice lacking sodium channel beta subunits via paradoxical effects on
persistent sodium currents, in revision.

These model files were supplied by Marie-Therese Horstmann.

Usage:
------

Check that you have NEURON installed (available from
http://www.neuron.yale.edu). Autolaunch from ModelDB **or** download
and extract the archive and compile the mod files to run under ...

linux/unix
----------
by typing
nrnivmodl
in the top level directory.  Then type
nrngui mosinit.hoc

mswin
-------

Run mknrndll, cd to the expanded directory and press make nrnmech.dll
button.  Double click on the mosinit.hoc file.

MAC OS X
--------

Drag and drop the expanded folder onto mknrndll icon in the NEURON
application folder. Drag and drop the mosinit.hoc file onto the nrngui
icon to start the simulation.

Once the simulation is running:
-------------------------------

Click the "Run simulation/graph then write file" button to recreate
figure 9A from the paper:



The simulation takes 7 minutes on a linux 2.8GHz pentium 4. You can
check whether it's running or not by looking at the "t" parameter
which shows the current "model time". You can stop the simulation by
the "stop" button. There is a 500ms pre-iteration period before the
current stimulation. The model needs this time to establish a steady
state. The membrane voltage trace from soma is written in a file
called "outputdata.dat" in the directory, where the model is
located. This is a plain ascii file. One data point corresponds to
0.25ms.  You can also, of course, change the model parameters varied
in the publication above.

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