| Respiratory central pattern generator network in mammalian brainstem (Rubin et al. 2009) |
| Accession: 125529 |
This model is a reduced version of a spatially organized respiratory central pattern generation network consisting of four neuronal populations (pre-I, early-I, post-I, and aug-E). In this reduction, each population is represented by a single neuron, in an activity-based framework (which includes the persistent sodium current for the pre-I population). The model includes three sources of external drive and can produce several experimentally observed rhythms.
Reference: Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA (2009) Multiple rhythmic states in a model of the respiratory central pattern generator. J Neurophysiol 101:2146-65 [PubMed] |
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This is the readme for the model associated with the paper:
Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA (2009)
Multiple rhythmic states in a model of the respiratory central pattern
generator. J Neurophysiol 101:2146-65
This models runs under XPP available from
http://www.math.pitt.edu/~bard/xpp/xpp.html
After downloading and extracting the archive the program can be
started for example under linux by cd'ing to the new folder and typing
xppaut rubinetal_resp_cpg.ode
Click on Initialconds -> Go
When complete click on Window/zoom -> (W)indow and then change "X Hi"
to 10000 and click OK. Then you should see a graph like:
which is similar to the first trace in Figure 2A from the paper.
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