| A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007) |
| Accession: 125857 |
One of the cellular mechanisms underlying the generation of gamma oscillations is a type of cortical pyramidal neuron named fast rhythmic bursting (FRB) cells. After cells from cats' primary visual cortices were filled with Neurobiotin, the brains were cut, and the cells were photographed. One FRB cell was chosen to be confocaled, reconstructed with Neurolucida software, and generated a detailed multi-compartmental model in the NEURON program. We explore firing properties of FRB cells and the role of enhanced Na+ conductance.
Reference: Lee, J (2007) Fast Rhythmic Bursting Cells: The Horizontal Fiber System in the Cat’s Primary Visual Cortex Penn McNair Research Journal 1(1):1 |
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This is the readme for the models associated with the paper
Lee, Jin (2007) "Fast Rhythmic Bursting
Cells: The Horizontal Fiber System in the Cat`s Primary Visual
Cortex" Penn McNair Research Journal: Vol. 1: Iss. 1, Article 1
These NEURON models (NEURON is available from http://www.neuron.yale.edu)
can be autolaunched from ModelDB to immediately start a simulation or download and extract
the archive, compile the mod files and then under
unix/linux:
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type
nrngui mosinit.hoc
at the command line
mac os X:
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drag and drop the mosinit.hoc file onto the nrngui icon
mswin:
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double click the mosinit.hoc file in the extracted folder
after the simulation starts:
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First select a cell from the menu, for example FRB.
The morphologies of this model match those shown in figure 3C of the paper.
Press the "Init & Run" button.
When the simulation is complete you should see a figure like:
February 22nd, 2010: These files were updated to include data files so that
the additional FRB_12_19 and FRB_12_21 simulations can be run.
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