ModelDB: Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)

Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)

Accession: 127996

Electrical synapses between interneurons contribute to synchronized firing and network oscillations in the brain. However, little is known about how such networks respond to excitatory synaptic input. In addition to detailed electrophysiological recordings and histological investigations of electrically coupled Golgi cells in the cerebellum, a detailed network model of these cells was created. The cell models are based on reconstructed Golgi cell morphologies and the active conductances are taken from an earlier abstract Golgi cell model (Solinas et al 2007, accession no. 112685). Our results show that gap junction coupling can sometimes be inhibitory and either promote network synchronization or trigger rapid network desynchronization depending on the synaptic input. The model is available as a neuroConstruct project and can executable scripts can be generated for the NEURON simulator.
Reference: Vervaeke K, Lorincz A, Gleeson P, Farinella M, Nusser Z, Silver RA (2010) Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input. Neuron 67:435-451 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Cerebellum;
Cell Type(s):	Cerebellar golgi cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I A; I K; I M; I K,Ca; I Calcium; I Potassium; I_AHP;
Gap Junctions:	Gap junctions;
Receptor(s):	GabaA; AMPA;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	neuroConstruct (web link to model);
Model Concept(s):	Ion Channel Kinetics; Oscillations; Synchronization; Detailed Neuronal Models;
Implementer(s):	Gleeson, Padraig [p.gleeson at ucl.ac.uk]; Vervaeke, Koen [k.vervaeke at ucl.ac.uk];

Search NeuronDB for information about: GabaA; AMPA; I Na,p; I Na,t; I L high threshold; I A; I K; I M; I K,Ca; I Calcium; I Potassium; I_AHP; Gaba; Glutamate;

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Note from the ModelDB Administrator: The following is an excerpt taken on August 18th 2010 from the Neuroconstruct projects page which contains a link to the Vervaeke et al. 2010 Golgi cell network model.

VervaekeEtAl-GolgiCellNetwork

Project name: VervaekeEtAl-GolgiCellNetwork

Network of electrically coupled cerebellar Golgi cells, as described in Vervaeke et al. Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input, Neuron 2010.

Project last modified: Thursday August 12, 2010

Downloads*:

neuroConstruct project

* Note: neuroConstruct project downloads (most of which are included with the standard software distribution) can be loaded directly into neuroConstruct to generate cell and network scripts for NEURON, GENESIS, etc., but NeuroML downloads just consist of the core elements of the project (morphologies, channels, etc.) which have been exported in NeuroML format. The latter can be useful for testing NeuroML compliant applications. If no NeuroML download link is present, this usually indicates that the model is mainly implemented using channel/synapse mechanisms in a simulator's native language (e.g. mod files) which have not fully been converted to ChannelML yet.

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