ModelDB: Stochastic ion channels and neuronal morphology (Cannon et al. 2010)

Stochastic ion channels and neuronal morphology (Cannon et al. 2010)

Accession: 128043

"... We introduce and validate new computational tools that enable efficient generation and simulation of models containing stochastic ion channels distributed across dendritic and axonal membranes. Comparison of five morphologically distinct neuronal cell types reveals that when all simulated neurons contain identical densities of stochastic ion channels, the amplitude of stochastic membrane potential fluctuations differs between cell types and depends on sub-cellular location. ..." The code is downloadable and more information is available at http://www.psics.org/
Reference: Cannon RC, O`Donnell C, Nolan MF (2010) Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS Comput Biol [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Synapse; Channel;
Brain Region(s)/Organism:
Cell Type(s):	Dentate granule cell; CA1 pyramidal neuron; Nigral dopaminergic cell; Neocortical pyramidal neuron: deep; Cerebellar purkinje cell;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	PSICS;
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s):

Search NeuronDB for information about: Dentate granule cell; CA1 pyramidal neuron; Nigral dopaminergic cell; Neocortical pyramidal neuron: deep; Cerebellar purkinje cell; I Na,t; I A; I K; I h;

Model files

Help downloading and running models

This is the readme for the model code for the paper:

Cannon RC, O`Donnell C, Nolan MF (2010) Stochastic ion channel gating
in dendritic neurons: morphology dependence and probabilistic synaptic
activation of dendritic spikes. PLoS Comput Biol

These model files were contributed by Matt Nolan and Cian O'Donnell.

The code for figures 2, 5, 6&7, 8&9 are supplied in the fig2, fig5,
figs6and7, and figs8and9 folders.

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