ModelDB: Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

Accession: 128446

The model reproduces short term plasticity of the mossy fibre to granule cell synapse. To reproduce synaptic currents recorded in experiments, a model of presynaptic release was used to determine the concentration of glutamate in the synaptic cleft that ultimately determined a synaptic response. The parameters of facilitation and depression were determined deconvolving AMPA EPSCs.
Reference: Nieus T, Sola E, Mapelli J, Saftenku E, Rossi P, D'Angelo E (2006) LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions. J Neurophysiol 95:686-99 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Synapse;
Brain Region(s)/Organism:
Cell Type(s):	Cerebellar granule cell;
Channel(s):
Gap Junctions:
Receptor(s):	AMPA; NMDA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	Neuron;
Model Concept(s):	Short-term Synaptic Plasticity;
Implementer(s):	Nieus, Thierry [thierry.nieus at iit.it];

Search NeuronDB for information about: Cerebellar granule cell; AMPA; NMDA; Glutamate;

Model files

Help downloading and running models

ShortTermPlasticityMFGRC_Nieus2006

Figure7_of_Nieus2006_Demo.hoc

init.ses

The files refer to the model published in the paper:

"LTP regulates burst initiation and frequency at mossy fiber-granule
cell synapses of rat cerebellum: experimental observations and
theoretical predictions." Nieus T, Sola E, Mapelli J, Saftenku E,
Rossi P, D'Angelo E.  J Neurophysiol. 2006 Feb;95(2):686-99"

These files were contributed by Thierry Nieus.

The scripts reproduce Figure 7 of the paper. The control condition,
release probability (U) = 0.416, is set by default. To reproduce the
right panel of the figure set release probability, the variable ''MF
to GRC synapse Prel'', equal to 0.6.

To run:
-------
Either auto-launch from ModelDB (after NEURON, available from
http://www.neuron.yale.edu, is installed) or
1) download and extract the files.
2) Compile the mod files as usual on your platform (run mknrndll under
windows, execute nrnivmodl in the extracted directory under linux, or
drag and drop the extracted folder onto the mknrndll icon under mac os
x).
3) Then start mosinit.hoc (double click on mosinit.hoc in windows,
type "nrngui mosinit.hoc" in linux, or drag and drop the mosinit.hoc
file onto the nrngui icon in mac os x).

Once the simulation is running press the Init & Run button.  The
following panels relevant to the left panel of Figure 7 will be
generated:

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