ModelDB: Four cortical interneuron subtypes (Kubota et al. 2011)

Four cortical interneuron subtypes (Kubota et al. 2011)

Accession: 140299

" ... Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to all. First, cross-sectional areas at any given point within a dendrite were proportional to the summed length of all dendritic segments distal to that point. ... Second, dendritic cross-sections became progressively more elliptical at more proximal, larger diameter, dendritic locations. Finally, computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic compartments. ..."
Reference: Kubota Y,Karube F, Nomura M, Gulledge AT, Mochizuki A, Schertel A, Kawaguchi Y (2011) Conserved properties of dendritic trees in four cortical interneuron subtypes Scientific Reports 1(89):1-13

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Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):
Implementer(s):	Nomura, Masaki [nomura at rcai.riken.jp];

Model files

Help downloading and running models

KubotaEtAl2011

readme.html

screenshot.jpg

BE77C_length_adjusted_NoActive.hoc

LV38E_length_adjusted_NoActive.hoc

mosinit.hoc

BE17B_length_adjusted_NoActive.hoc

run.hoc

runcontrol.hoc

BE59D_length_adjusted_NoActive.hoc

model.ses

gui.ses

graph.ses

This is the readme for the model associated with the paper:

Yoshiyuki Kubota, Fuyuki Karube, Masaki Nomura, Allan T. Gulledge,
Atsushi Mochizuki, Andreas Schertel & Yasuo Kawaguchi (2011)
Conserved properties of dendritic trees in four cortical interneuron
subtypes. Scientific Reports 1(89):1-13

These files were contributed by Masaki Nomura.

Example use: auto-launch from ModelDB (after NEURON is installed) or
download the archive and run with appropriate OS command:

(linux) type the command "nrngui run.hoc" at the shell prompt after
cd'ing to the folder created when the archive was expanded.
(mswin) double click the run.hoc file in windows explorer.
(mac) drag and drop the folder created when the archive was expanded
onto the nrngui icon.

Once the simulation is started you can select a cell type, for
example, click the Martinotti cell, BE17BNoActive, and then click the
RunControl, and PointManager buttons.  In the PointManager click
SelectPointProcess -> AlphaSynapse PointProcess and set onset=10ms,
tau=1ms, gmax=0.002. From the NEURON Main Menu select Graph -> Voltage
axis. Press Init & Run button on the RunControl window and you should
see a graph like a trace in Figure 6a left panel:

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