ModelDB: A four compartmental model for ABPD complex in crustacean pyloric network (Maran et al. 2011)

A four compartmental model for ABPD complex in crustacean pyloric network (Maran et al. 2011)

Accession: 141192

"Central pattern generators (CPGs) frequently include bursting neurons that serve as pacemakers for rhythm generation. Phase resetting curves (PRCs) can provide insight into mechanisms underlying phase locking in such circuits. PRCs were constructed for a pacemaker bursting complex in the pyloric circuit in the stomatogastric ganglion of the lobster and crab. ..."
Reference: Maran SK, Sieling FH, Demla K, Prinz AA, Canavier CC (2011) Responses of a bursting pacemaker to excitation reveal spatial segregation between bursting and spiking mechanisms. J Comput Neurosci [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Stomatogastric ganglion;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	C or C++ program;
Model Concept(s):	Bursting;
Implementer(s):

Model files

Help downloading and running models

multicompartmentABPDcomplex_model

This is the sourse code for the model used in the following paper:

Maran SK, Sieling FH, Demla K, Prinz AA, Canavier CC. "Responses of a
bursting pacemaker to excitation reveal spatial segregation between
bursting and spiking mechanisms". J Comput Neurosci. 2011 Mar 1.
[Epub ahead of print]
PubMed PMID: 21360137; PubMed Central PMCID: PMC3160527.

There are three files - ABPDdriver.c, ABPDcon.h and ABPD.h.
	ABPDcon.h has the values for different parameters such as
	conductance strength, reversal potentials etc
	ABPD.h has the code for kinetic equations and current
	equations of different channels. Also the code for numerical
	method.
	ABPDdriver.c has the main function.

To run simulation compile the ABPDdriver file - for example 

gcc -lm ABPDdriver.c

to get executable file and run the executable file with "./a.out".
The simulation will create the file tm_volts.xls that contains the
time in first column and somatic voltage values in the second
column. The units are x-axis in milliseconds and y-axis in millivolts.
The output is the somatic voltage trace of the model during
spontaneous bursting:



If you have any questions/comments please contact selvamaran@gmail.com.

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