| Network model with neocortical architecture (Anderson et al. 2011 plus under review paper) |
| Accession: 141507 |
Architecturally realistic neocortical model using seven classes of excitatory and inhibitory single compartment Hodgkin-Huxley cells. This is an addendum to ModelDB Accession # 98902, Studies of stimulus parameters for seizure disruption (Anderson et al. 2007). Wiring is adapted from the minicolumn hypothesis and incorporates visual and neocortical wiring data. Simulation demonstrates spontaneous bursting onset and cessation. This activity can be induced by random fluctuations in the surrounding background input (Manuscript in preparation).
Reference: Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ (2007) Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 97:173-94 [PubMed] |
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| Search NeuronDB for information about: Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial; Neocortical basket cell; AMPA; Gaba; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; |
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| These are the files for a paper under review: and a fresh paper:
Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic
seizures from abnormal networks: Why some seizures defy
predictability. Epi Res doi: 10.1016/j.eplepsyres.2011.11.006.
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