ModelDB: Basal ganglia-thalamic network model for deep brain stimulation (So et al. 2011)

Basal ganglia-thalamic network model for deep brain stimulation (So et al. 2011)

Accession: 141699

This is a model of the basal ganglia-thalamic network, modified from the Rubin and Terman model (High frequency stimulation of the Subthalamic Nucleus, Rubin and Terman 2004). We subsequently used this model to investigate the effectiveness of STN and GPi DBS as well as lesion when various proportions of local cells and fibers of passage were activated or silenced. The BG network exhibited characteristics consistent with published experimental data, both on the level of single cells and on the network level. Perhaps most notably, and in contrast to the original RT model, the changes in the thalamic error index with changes in the DBS frequency matched well the changes in clinical symptoms with changes in DBS frequency.
Reference: So RQ, Kent AR, Grill WM (2011) Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study. J Comput Neurosci [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Thalamic relay neuron; Subthalamic projection neuron; Globus pallidus neuron;
Channel(s):	I Na,t; I T low threshold; I K; I K,Ca; I Calcium; I Cl, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	MATLAB;
Model Concept(s):	Activity Patterns; Bursting; Parkinson's; Deep brain stimulation;
Implementer(s):	So, Rosa ;

Search NeuronDB for information about: Thalamic relay neuron; I Na,t; I T low threshold; I K; I K,Ca; I Calcium; I Cl, leak;

Model files

Help downloading and running models

These are the model files for the paper:

So RQ, Kent AR, Grill WM. (2011) Relative contributions of local cell
and passing fiber activation and silencing to changes in thalamic
fidelity during deep brain stimulation and lesioning: a computational
modeling study. J Comput Neurosci 2011 Oct 5

These files are written in Matlab. Make sure you have Matlab installed. 

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To Launch model: Run initial.m by typing initial on the matlab command
line. Allow around three minutes for script to finish.

This will output the error index (EI) for the conditions of healthy,
Parkinson's Disease (PD), and PD with deep brain stimulation at 130Hz.
Figures 1,2 and 3 will plot example membrane potentials for thalamic,
subthalmic nucleus (STN) and globus pallidus neurons under the
healthy, PD, and PD+DBS conditions respectively.





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To Change Parameters:

Using the fuction BGnetwork.m, you can change whether it is under the
healthy or PD conditions, whether deep brain stimulation is applied,
and the frequency of stimulation.

By default, stimulation is applied to the STN.

To change stimulation location, add or delete "+Idbs(i)" to
differential equations for membrane potentials vsn, vge or vgi.

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