ModelDB: Phase response curve of a globus pallidal neuron (Fujita et al. 2011)

Phase response curve of a globus pallidal neuron (Fujita et al. 2011)

Accession: 143100

We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current.
Reference: Fujita T, Fukai T, Kitano K (2011) Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron. [epub ahead of print] J Comput Neurosci [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Globus pallidus neuron;
Channel(s):	I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Ions;
Simulation Environment:	Neuron;
Model Concept(s):	Synchronization; Parkinson's; Phase Response Curves;
Implementer(s):	Kitano, Katsunori [kitano at ci.ritsumei.ac.jp];

Search NeuronDB for information about: I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1; Ions;

Model files

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Single compartmental model of a Globus pallidus neuron

Tomohiro Fujita, Tomoki Fukai and Katsunori Kitano (2011)
"Influences of membrane properties on phase response curve and
synchronization stability in a model globus pallidus neuron"
Journal of Computational Neuroscience
DOI: 10.1007/s10827-011-0368-2

The original model is proposed by Gunay et al.(2008) as a
multi-compartmental model.  We modified values of ionic conductances
so that the single compartmental model shows the similar firing
activity to that of the original model.

Autolaunch or after building the mod files, run the demo.hoc file.

The demo corresponds to Figure 1(a) and (b) in the paper.  To generate
1(a) from the Neuron Main Menu select Tools -> Point Processes ->
Managers -> Point Group.  Change the IClamp delay to 500, duration to
1000 and current to either -.003, 0, .003, .006 nA to correspond to
-1, 0, 1, 2 uA/cm2.  If on the voltage graph you select Keep lines
from the upper left box menu (or right click on the graph), after
running with the above values your graph should look similar to:

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