ModelDB: Spike repolarization in axon collaterals (Foust et al. 2011)

Spike repolarization in axon collaterals (Foust et al. 2011)

Accession: 143442

Voltage sensing dye experiments and simulations characterize the location and re-polarizing function of Kv1 channels in cortical neurons. "... (the papers) results indicate that action potential-induced synaptic transmission may operate through a mix of analog–digital transmission owing to the properties of Kv1 channels in axon collaterals and presynaptic boutons."
Reference: Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011) Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons The Journal of Neuroscience 31(43):15490-15498 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial;
Channel(s):	I Na,t; I K; I_KD;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potentials;
Implementer(s):

Search NeuronDB for information about: Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial; I Na,t; I K; I_KD;

Model files

Help downloading and running models

AIS_axon_uniform6_withMyelin090211.hoc

mosinit.hoc

This is the readme for the model code for the paper

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011)
Somatic membrane potential and Kv1 channels control spike
repolarization in cortical axon collaterals and presynaptic boutons
The Journal of Neuroscience 31(43):15490-15498

These files were supplied by Amanda Foust.

To run auto-launch from ModelDB or download and extract the archive,
compile the mod files with mknrndll (windows or mac), or nrnivmodl
(linux).  Double click the mosinit.hoc file (windows) or drag and drop
mosinit.hoc on the nrngui icon (mac), or type the command "nrngui
mosinit.hoc" (linux).

Once started you can click the "inject node" button.  Some voltage and
current traces will be displayed, for example:



The default parameters correspond to the top traces in figure 4B and
those in figure 4C in the paper.

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University