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Active dendritic action potential propagation (Casale & McCormick 2011)
Accession: 143635
This model explores the dendritic sodium and potassium conductances needed to recapitulate voltage-sensitive dye optical recordings of thalamic interneuron dendrites in the dorsal lateral geniculate nucleus. Model ion channels were selected based on pharmacological data.
Reference: Casale AE, McCormick DA (2011) Active action potential propagation but not initiation in thalamic interneuron dendrites. J Neurosci 31:18289-302 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  Thalamus;
Cell Type(s):   Thalamic Interneuron in dorsal LGN;
Channel(s):  I Na,t; I_KHT;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  Neuron;
Model Concept(s):  Dendritic Action Potentials; Conductance distributions;
Implementer(s):  Casale, Amanda [Amanda.Casale at yale.edu];
Search NeuronDB for information about:  I Na,t; I_KHT;
\
CasaleEtAl2011
Readme.html
screenshot.jpg
kht.mod
mhw.mod
na.mod
mosinit.hoc
mosinit_setup5_NaDend100t0_axon.hoc
mosinit_setup5_NaDend5025_axon.hoc
mosinit_setup5_NoNaDend_axon.hoc
cell_setup5_NoNaDend_axon.hoc
cell_setup5_NaDend100t0_axon.hoc
cell_setup5_NaDend5025_axon.hoc
rig.ses
iclamp.ses
spaceplot.ses
                            
This is the readme for the model associated with the paper

Casale AE, McCormick DA (2011) Active action potential propagation but
not initiation in thalamic interneuron dendrites.
J Neurosci 31:18289-302

These files were contributed by Amanda Casale.

General description of the model:

This model explores conductance distributions in dendrites for
comparison to voltage-sensitive dye optical recordings from
thalamic interneuron dendrites in the dorsal lateral geniculate
nucleus.
The purpose is to assess action potential kinetics and amplitude in
thalamic interneuron dendrite models under different dendritic
conductance distributions.

Example Use:

The auto-launch (mosinit.hoc) will start the simulation with the
configuration that most closely matched experiment. Compile the mod
files first with mknrndll (MAC and mswin) or nrnivmodl (linux/unix) if
starting manually. Click the measure button to run the simulation and
generate graphs of kinetics.  A graph similar to that in Figure 10E's
50-25% red line is among those displayed:

screenshot

Description of key files:

cell_setup5_''
These files will define each cell conductance distribution for
comparison against the real cell.
Active Axon = 50 to 25% condition
Full Grad = 100 to 0% condition
No Na Dend = 0% sodium condition (our passive condition)

mosinit_setup5_''
These files will run the individual conditions.
In Windows Explorer double click a mosinit_setup5_'' to run
simulation.
Click the "measure" button to generate graphs of kinetics.

mhw.mod
Measures peak depol and calculates spike half width, 10-90% rise time,
and 90-10% fall time.  Threshold may be specified by the user, or
determined in the previous run.

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