ModelDB: Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

Accession: 20756

This simulation is based on the reference paper listed below.

This port was made by Roger D Traub and Maciej T Lazarewicz (mlazarew@seas.upenn.edu) Thanks to Ashlen P Reid for help with porting a morphology of the cell.

Reference: Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast Rhythmic Bursting Can Be Induced in Layer 2/3 Cortical Neurons by Enhancing Persistent Na(+) Conductance or by Blocking BK Channels. J Neurophysiol 89:909-21 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortical pyramidal neuron: superficial;
Channel(s):	I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Dendritic Action Potentials; Bursting; Active Dendrites; Detailed Neuronal Models; Axonal Action Potentials; Calcium dynamics;
Implementer(s):	Lazarewicz, Maciej [mlazarew at gmu.edu]; Traub, Roger D ;

Search NeuronDB for information about: Neocortical pyramidal neuron: superficial; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;

Model files

Help downloading and running models

This port was made from the FORTRAN code into the NEURON enviroment based on 

	Traub RD, Buhl EH, Gloveli T, Whittington MA. 
	Fast Rhythmic Bursting Can Be Induced in Layer 2/3 Cortical Neurons by 
	Enhancing Persistent Na(+) Conductance or by Blocking BK Channels.
	J Neurophysiol. 2003 Feb; 89(2):909-21

This port was made by Roger D Traub and Maciej Lazarewicz (mlazarew@seas.upenn.edu)

Thanks to Ashlen P Reid for help with porting a morphology of the cell.

This port is reproducing figures 2, 4, 5, 6 and 7.

Under unix systems:
-------------------
to compile the mod files use the command

 nrnivmod

and run the simulation hoc file with the command

 nrngui pyr3.hoc


Under Windows systems:
----------------------

to compile the mod files use the "mknrndll" command.
A double click on the simulation file

 pyr3.hoc

will open the simulation window.

Questions on how to use this port should be directed to mlazarew@seas.upenn.edu

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