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| Representative Simulations for
Wang, X.-J. and Buzsaki G. (1996) Gamma oscillations by synaptic inhibition in a
hippocampal interneuronal network. J. Neurosci. 16, 6402-6413.
Fig. 1a
Small discrepancies between gif background in Grapher and the simulation is
probably due to slightly incorrect scaling and origin of the gif.
Default parameters replicate Fig. 3A (phi0=5; current injection amp0=1 muA/cm2).
Fig. 3B parameters are (phi0=3.3; amp0=1.2); 3C (phi0=2.0; amp0=1.4).
Note: this simulation takes a little more than 3 minutes on a 2GH linux machine.
Start the simulation by pressing the Run button or the Init&Run button.
When the simulation stops, press the "Spike plot" button and the
"Plot cells A&B" button.
Parameter control panel permits change in parameters as follows:
phi phi0
Current inj. amp0
Run redundant with run button on run control
Randomize rerandomizes initial conditions
(Chosen as a uniform distribution between -68 and -55 mV;
this range was chosen to give sync at approximately the cycle
seen in the paper.)
Spike Plot Put up a graph of spike times
(Note that you can stop simulation, put up a graph, and restart.
This graph is only a snapshot and will not be updated.)
Plot cells A&B Overlay 2 cells' voltage plots. Cell # chosen below must be
between 0 and 99. Horizontal lines are drawn at -52 and -75 mV to
compare with right-side graphs of Fig. 3 in paper.
Cell A Choose cell to plot.
Cell B Choose other cell to plot.
Technical notes:
In the original paper, current injection is given
in units of mA/cm2. Here we have chosen a cell size of 100um/cm2
so that nA is equivalent to mA/cm2.
In the original paper, phi directly alters the time constant as a factor in the
differential equation. In this implementation, phi(phi0) alters celsius appropriately.
Bill Lytton developed the fig 3a simulation and model descriptions. Michael
Hines created the fig1a gui.
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