| Thalamocortical augmenting response (Bazhenov et al 1998) |
| Accession: 37819 |
In the cortical model, augmenting responses were more powerful in the "input" layer compared with those in the "output" layer. Cortical stimulation of the network model produced augmenting responses in cortical neurons in distant cortical areas through corticothalamocortical loops and low-threshold intrathalamic augmentation. ... The predictions of the model were compared with in vivo recordings from neurons in cortical area 4 and thalamic ventrolateral nucleus of anesthetized cats. The known intrinsic properties of thalamic cells and thalamocortical interconnections can account for the basic properties of cortical augmenting responses. See reference for details. NEURON implementation note: cortical SU cells are getting slightly too little stimulation - reason unknown.
Reference: Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (1998) Computational models of thalamocortical augmenting responses. J Neurosci 18:6444-65 [PubMed] |
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| Bazhenov thalamocortical augmenting response model
replicates Fig. 6B
Maxim Bazhenov, Igor Timofeev, Mircea Steriade, and Terrence J. Sejnowski
Computational Models of Thalamocortical Augmenting Responses
J. Neurosci. 1998 18: 6444-6465.
Usage :
nrnivmodl
nrngui batch_.hoc
NOTE:
Simulation replicated directly from M. Bazhenov's C++ file.
Cortical SU cells are getting too little stimulation; I was unable to find the
parameter discrepancy that accounted for this.
This simulation takes a couple of minutes to run on a 800 MHz Pentium III mswin pc.
target simulation shown in jnsci18_6444F6B.jpg
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