| Kenyon cells in the honeybee (Wustenberg et al 2004) |
| Accession: 42022 |
The mushroom body of the insect brain is an important locus for olfactory information
processing and associative learning. ... Current- and voltage-clamp analyses were
performed on cultured Kenyon cells from honeybees. ... Voltage-clamp analyses characterized a
fast transient Na+ current (INa), a delayed rectifier K+ current (IK,V) and a fast transient K+ current
(IK,A). Using the neurosimulator SNNAP, a Hodgkin-Huxley type model was developed and
used to investigate the roles of the different currents during spiking. The model led to the
prediction of a slow transient outward current (IK,ST) that was subsequently identified by reevaluating
the voltage-clamp data. Simulations indicated that the primary currents that underlie
spiking are INa and IK,V, whereas IK,A and IK,ST primarily determined the responsiveness of the
model to stimuli such constant or oscillatory injections of current. See paper for more details.
Reference: Wustenberg DG, Boytcheva M, Grunewald B, Byrne JH, Menzel R, Baxter DA (2004) Current- and voltage-clamp recordings and computer simulations of Kenyon cells in the honeybee. J Neurophysiol : [PubMed] |
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| Readme for Kenyon cells in the honeybee model by Wustenberg et al 2004
This model was used in the publication
Wustenberg DG, Boytcheva M, Grunewald B, Byrne JH, Menzel R, Baxter DA
Current- and voltage-clamp recordings and computer simulations of Kenyon cells in the honeybee.
J Neurophysiol. 2004 Jun 9 (epub ahead of print)
to use:
Download and expand the zip file into a directory that contains no spaces in it's path.
Double click on the SNNAP8.jar file in the SNNAP directory. Click on Run Simulation, then
on the new window click File --> Load Simulation and select the available file. Finally
click on HHKenyon.smu and then Start. The simulation produces a figure similar to fig 9B1.
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