ModelDB: Minimal cell model (Av-Ron et al 1991)

Minimal cell model (Av-Ron et al 1991)

Accession: 42047

The minimal cell model (MCM) is a reduced Hodgkin-Huxley model that can exhibit excitable and oscillatory behavior. It consists of two ordinary differential equations, dV/dt for membrane voltage and dW/dt for potassium activation and sodium inactivation. The MCM has a stable membrane potential of -60mV. With constant input current of 10uA/cm2, it exhibits oscillations of 150Hz. It is based on the work by FitzHugh and Rinzel.
Reference: Av-Ron E, Parnas H, Segel LA (1991) A minimal biophysical model for an excitable and oscillatory neuron. Biol Cybern 65:487-500 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	SNNAP;
Model Concept(s):	Simplified Models; Action Potentials; Invertebrate;
Implementer(s):	Av-Ron, Evyatar ;

Search NeuronDB for information about: I Potassium; I Sodium;

Model files Help downloading and running models

The Minimal Cell Model (MCM) :

Av-Ron, E, Parnas, H, Segel, LA (1991) A minimal biophysical model for
an excitable and oscillatory neuron.
Biol. Cybern. 65:487-500

implemented in SNNAP (http://snnap.uth.tmc.edu).

The minimal cell model (MCM) is a reduced Hodgkin-Huxley model that can
exhibit excitable and oscillatory behavior. It consists of two
ordinary differential equations, dV/dt for membrane voltage and dW/dt
for potassium activation and sodium inactivation. The MCM has a stable
membrane potential of -60mV. With constant input current of 10uA/cm2, it
exhibits oscillations of 150Hz. It is based on the work by FitzHugh and
Rinzel.

Provided by Evyatar Av-Ron <eav-ron@uth.tmc.edu>

To run:

Download and unzip the zip file into a directory that has no spaces in its path.

Double click on the SNNAP8.jar file (where the 8 might be a different version)

Click on start simulation, then File--> Load simulation and browse to the MCM folder and
select the MCM.smu file.

Finally click on start.

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